Glucagon and insulin hypoglycaemia

Impaired ACTH and glucagon response to hypoglycaemia in an insulin-treated diabetic.

A 32-year-old woman who had been diabetic for 24 years presented with frequent, oligosymptomatic episodes of hypoglycaemia. Investigations showed that she had attenuated adrenocortical and pancreatic A-cell response to hypoglycaemia. Her plasma ACTH response to hypoglycaemia was also impaired but there was normal adrenocortical response to the injection of synthetic ACTH. Plasma glucagon respon...

Ketotic (idiopathic glucagon unresponsive) hypoglycaemia: diazoxide effects.

Persistent neonatal hypoglycaemia due to glucagon deficiency.

In a newborn baby, suffering from persistent severe hypoglycaemia with convulsions glucagon deficiency was shown. Treatment with zinc-protamine-glucagon injection twice daily resulted in normal blood glucose levels. Motor development is delayed.

Continuous intraperitoneal insulin infusion partly restores the glucagon response to hypoglycaemia in type 1 diabetic patients.

The glycaemic and hormonal responses to a hypoglycaemic event induced by an i.v. bolus of insulin was studied in seven type 1 diabetic patients treated first with continuous subcutaneous insulin infusion (CSII) and subsequently with continuous intraperitoneal insulin infusion (CIPII). Arterialised blood glucose and venous hormonal responses were analyzed. HbA1c was improved by CIPII. Although a...

Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

INTRODUCTION In healthy carriers of the T allele of the transcription factor 7-like 2 (TCF7L2), fasting plasma glucagon concentrations are lower compared with those with the C allele. We hypothesised that presence of the T allele is associated with a diminished glucagon response during hypoglycaemia and a higher frequency of severe hypoglycaemia (SH) in type 1 diabetes (T1DM). MATERIAL AND ME...